ENTnano™ — a New Vision for Precision and Access in ENT Care
Every year in the United States, 6 to 8 million patients develop sinus infections that progress to chronic or severe stages, ultimately requiring surgical intervention. Yet, despite the prevalence of these conditions, Ear, Nose, and Throat (ENT) surgeons continue to face major barriers in both diagnosis and treatment.
The Challenge
Sinus, ear, and laryngeal disorders are often hidden within narrow, complex anatomical spaces that are difficult to access or visualize. In many procedures, surgeons must rely on limited tactile feedback or indirect imaging. Traditional visualization methods—such as CT or MRI—are valuable for structural assessment, but they lack the real-time, direct imaging necessary for precision interventions.
Existing steerable or flexible endoscopes, while technologically advanced, remain constrained by their size, cost, and reusability concerns. Their large diameter limits access to delicate regions such as the sinus ostia, middle ear, and subglottic airway. High acquisition and sterilization costs often make them impractical for lower-budget or outpatient settings, and repeated reuse raises infection-control challenges.
A New Era of Precision: The ENTnano™ Solution
ENTnano™, a subsidiary of LuminusMicro, is focused on advancing the concept of an entirely new class of microsurgical visualization system — reimagining how microscale imaging could one day provide high-definition, direct views within delicate anatomy.
Built on LuminusMicro’s patented micro-optics platform, ENTnano™ is being developed to explore new ways of seeing, navigating, and delivering treatment at the microscale — aiming to achieve visualization and access within anatomy measured near 1mm in diameter.
With chronic sinus disease as one of the most common—and often recurrent—conditions seen in ENT practice, clinical studies show that recurrence and revision rates can reach 40–50 % in patients with chronic or complex disease, underscoring the urgent need for better visualization and treatment tools.
ENTnano™ was conceived with the goal to give every ENT surgeon the clarity and precision needed to improve patient outcomes while reducing procedural complexity and cost.
Pursuing Simplicity and Precision
ENTnano™ represents ongoing development toward a new generation of microsurgical imaging and access technology. The platform’s research and design efforts focus on advancing real-time visualization and precision control at the smallest scale — aiming to address current limitations in how surgeons visualize and reach delicate anatomy.
Future development goals for the ENTnano™ platform include technologies that could:
Enable real-time visualization of anatomy to complement traditional imaging methods
Explore ways to create access through narrow or constricted passages for improved inspection
Investigate approaches to reaching inflamed or obstructed regions with enhanced precision
Develop techniques to support targeted retrieval or excision of small tissue fragments
Advance localized therapeutic delivery concepts at the site of concern
The ENTnano™ X1 reflects a vision for single-use microsurgical innovation — pursuing integration of visualization and therapy in one compact, intuitive system.
Market Adoption and Clinical Collaboration
LuminusMicro has established strategic partnerships with leading ENT practices—collectively representing more than 2% of U.S. sinus procedures annually (approximately 120,000–160,000 cases). These early collaborators have contributed valuable insights to help optimize operational efficiency, surgeon ergonomics, and clinical utility.
With nearly 50% of current sinus procedures resulting in treatment failure or recurrence, the need for improved visualization and precision tools has never been greater.
Persistent recurrence rates in sinus surgery highlight an ongoing need for better visualization and precision at the microscale. ENTnano™ technology is under development with design goals that include:
Advancing visualization and precision access
Supporting single-use sterility to limit reprocessing concerns
Facilitating future integration into diverse clinical settings
Path to ENTnano Launch: July 2026
ENTnano™ is targeting a U.S. market introduction in July 2026, pending successful completion of regulatory clearance activities. The initial rollout will focus on meeting the needs of our existing surgeon network—providing early access, training, and workflow integration support.
Following this initial phase, LuminusMicro will expand production and distribution to serve broader ENT practices nationwide, with a focus on improving procedural efficiency, patient outcomes, and accessibility in both hospital and ambulatory settings.
